Technology Process of <1R-(1α,2β,3α,4β,5α,6α)>-5-(Benzyloxy)-3,4-bis(methoxymethoxy)-7-oxabicyclo<4.1.0>heptan-2-ol
There total 10 articles about <1R-(1α,2β,3α,4β,5α,6α)>-5-(Benzyloxy)-3,4-bis(methoxymethoxy)-7-oxabicyclo<4.1.0>heptan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
for 88h;
Ambient temperature;
DOI:10.1021/jo00124a023
- Guidance literature:
-
Multi-step reaction with 8 steps
1: P2O5 / CHCl3 / 1 h / 0 °C
2: NaI, n-Bu4NI, 4 Angstroem molecular sieves / dimethylsulfoxide / 2 h / 90 °C
3: DBU / dimethylsulfoxide / 20 h / 90 °C
4: 90 percent / NaOMe / methanol / 60 h / Heating
5: 86 percent / NaH / dimethylformamide / 1.) room temp., 30 min, 2.) room temp., 1 h
6: 2.) Ac2O / 1.) Hg(OCOCF3)2 / 1.) aq. acetone, room temp., 15 h, 2.) pyridine, room temp., 21 h
7: 86 percent / CeCl3*7H2O, NaBH4 / methanol / 0.5 h / 0 °C
8: 91 percent / m-CPBA / CH2Cl2 / 88 h / Ambient temperature
With
sodium tetrahydroborate; cerium(III) chloride; 4 A molecular sieve; sodium methylate; phosphorus pentoxide; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; sodium iodide;
mercury(II) trifluoroacetate;
In
methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00124a023
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / NaH / dimethylformamide / 1.) room temp., 30 min, 2.) room temp., 1 h
2: 2.) Ac2O / 1.) Hg(OCOCF3)2 / 1.) aq. acetone, room temp., 15 h, 2.) pyridine, room temp., 21 h
3: 86 percent / CeCl3*7H2O, NaBH4 / methanol / 0.5 h / 0 °C
4: 91 percent / m-CPBA / CH2Cl2 / 88 h / Ambient temperature
With
sodium tetrahydroborate; cerium(III) chloride; acetic anhydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
mercury(II) trifluoroacetate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00124a023
