(R)-1,2-dibenzylaziridine

Base Information

• Chemical Name: (R)-1,2-dibenzylaziridine
• CAS No.: 1234572-14-5
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.318
• Mol file: 1234572-14-5.mol

Synonyms:(R)-1,2-dibenzylaziridine

Chemical Property of (R)-1,2-dibenzylaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1,2-dibenzylaziridine

There total 4 articles about (R)-1,2-dibenzylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloride (100-44-7) + (R)-2-benzylaziridine (77184-95-3) → (R)-1,2-dibenzylaziridine (1234572-14-5)

Guidance literature:

(R)-2-benzylaziridine; In toluene; at 60 ℃;

benzyl chloride; With ammonium hydroxide; In toluene; at 30 - 35 ℃; for 3h;

Reference yield:

C16H18ClN → (R)-1,2-dibenzylaziridine (1234572-14-5)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 65 ℃;

DOI:10.1021/ol101276x

Reference yield:

(R)-2-amino-3-phenylpropanol (5267-64-1) → (R)-1,2-dibenzylaziridine (1234572-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / toluene / 0.5 h / 20 °C

1.2: 20 h / 80 °C

2.1: toluene / 60 °C

2.2: 3 h / 30 - 35 °C

With sulfuric acid; In toluene;

upstream raw materials:

benzyl chloride

(R)-2-benzylaziridine

(R)-2-amino-3-phenylpropanol

D-(R)-phenylalanine

Downstream raw materials:

N-Demethylbenzphetamine

Refernces

• 1、 Fadeyi, Olugbeminiyi O.,Schulte, Michael L.,Lindsley, Craig W.. "General access to chiral n -alkyl terminal aziridines via organocatalysis". supporting information; experimental part. p. 3276 - 3278. Retrieved 2010/10/21.