77184-95-3 Usage
Description
(R)-2-Benzyl-aziridine, a chiral aziridine with the molecular formula C9H11N, is a chemical compound featuring a small, strained ring structure containing nitrogen. Its unique three-membered ring and the presence of a benzyl group make it a significant starting material for creating diverse molecular scaffolds with a broad spectrum of potential applications. It is often utilized as a versatile intermediate in organic synthesis, particularly for the preparation of chiral building blocks and pharmaceuticals. Moreover, (R)-2-Benzyl-aziridine has been studied for its potential as a reagent in asymmetric synthesis, where it can introduce chirality into molecules and open new avenues for chemical reactions.
Uses
Used in Organic Synthesis:
(R)-2-Benzyl-aziridine is used as a versatile intermediate for the preparation of chiral building blocks and pharmaceuticals. Its unique structure allows for the creation of diverse molecular scaffolds, which are essential in the development of new drugs and other chemical compounds.
Used in Asymmetric Synthesis:
(R)-2-Benzyl-aziridine is used as a reagent in asymmetric synthesis to introduce chirality into molecules. This capability is crucial for the synthesis of enantiomerically pure compounds, which are often required in pharmaceuticals and other industries where the stereochemistry of a molecule can significantly impact its properties and effectiveness.
Used in Pharmaceutical Industry:
(R)-2-Benzyl-aziridine is used as a key component in the development of new pharmaceuticals. Its ability to create chiral building blocks and its potential in asymmetric synthesis make it a valuable tool in the synthesis of enantiomerically pure drug candidates, which can have improved therapeutic effects and reduced side effects compared to their racemic counterparts.
Used in Chemical Research:
(R)-2-Benzyl-aziridine is used as a research tool in the field of chemistry to explore new reactions and mechanisms involving chiral aziridines. Its unique properties and reactivity can provide insights into the behavior of strained ring systems and contribute to the advancement of synthetic methodologies and strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 77184-95-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,8 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77184-95:
(7*7)+(6*7)+(5*1)+(4*8)+(3*4)+(2*9)+(1*5)=163
163 % 10 = 3
So 77184-95-3 is a valid CAS Registry Number.
77184-95-3Relevant articles and documents
Preparation method of benzphetamine hydrochloride
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Paragraph 0071-0073; 0080-0085, (2020/01/25)
The invention relates to the field of chemical pharmacy, and in particular relates to a preparation method of benzphetamine hydrochloride. According to the method, the use of controlled products suchas ephedrine, pseudoephedrine, deoxyephedrine and the like is avoided; the raw materials are cheap and easy to obtain, so that the synthesis cost is reduced; by using the preparation method disclosedby the invention, the high-purity target compound can be obtained at high yield, and industrial large-scale production is easy.
A new and expeditious asymmetric synthesis of (R)- and (S)-2-aminoalkanesulfonic acids from chiral amino alcohols
Xu, Jiaxi
, p. 1129 - 1134 (2007/10/03)
The mechanism for the transformation of β-amino alcohol methanesulfonate hydrochlorides into sodium β-amino alkanesulfonates using sodium sulfite was investigated. The results show that sodium sulfite initially neutralizes the β-amino alcohol methanesulfonate hydrochloride to give a free β-amino alcohol methanesulfonate, which then cyclizes to a 2-alkylaziridine. Attack by the previously formed sodium bisulfite at the less hindered carbon atom of the aziridine ring then yields a β-amino alkanesulfate sodium salt. Based on this mechanistic proposal, a new and rapid asymmetric synthesis of (R)- and (S)-2-aminoalkanesulfonic acids from chiral amino alcohols was developed. Chiral amino alcohols were converted to chiral aziridines through the Wenker method or Mitsunobu reaction and the resulting aziridines were reacted with sodium bisulfite to produce chiral β-amino alkanesulfonic acids.
