3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

Base Information

Chemical Name:3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one
CAS No.:1073486-95-9
Molecular Formula:C₂₅H₂₁NO₃
Molecular Weight:383.447
Hs Code.:

Synonyms:3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

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Chemical Property of 3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

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Technology Process of 3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

There total 2 articles about 3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 62303-05-3
2-iodo-N-(p-tolyl)benzamide

: 2216-94-6
phenylpropynoic acid ethyl ester

: 1073486-95-9
3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

: 1236228-52-6
ethyl 1,2-dihydro-1-oxo-4-phenyl-2-p-tolylisoquinoline-3-carboxylate

Guidance literature:: With dibromo[1,2-bis(diphenylphosphino)ethane]nickel(II); triethylamine; zinc; In acetonitrile; at 80 ℃; Inert atmosphere;
DOI:10.1021/ol101371c

Reference yield: 60.0%

: 201230-82-2
carbon monoxide

: 128823-22-3
(2-iodophenyl)propanedioic acid diethyl ester

: 15999-95-8
4-methylphenylbenzimidoyl chloride

: 1073486-95-9
3-phenyl-2-(p-tolyl)-4-carboxylic acid ethyl ester-isoquinolin-1(2H)-one

Guidance literature:: With palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 120 ℃; for 48h; under 20686.5 Torr;
DOI:10.1021/ol801991m