N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide

Base Information

• Chemical Name: N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide
• CAS No.: 1106668-32-9
• Molecular Formula: C₃₁H₃₈F₅N₅O₃
• Molecular Weight: 623.666

Synonyms:N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide

Chemical Property of N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide

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Technology Process of N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide

There total 1 articles about N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(dipropylcarbamoyl)-1-ethyl-1H-pyrazole-3-carboxylic acid (1106669-02-6) + (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol (388075-42-1) → N3-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N5,N5-dipropyl-1H-pyrazole-3,5-dicarboxamide (1106668-32-9)

Guidance literature:

5-(dipropylcarbamoyl)-1-ethyl-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol; In N,N-dimethyl-formamide; for 72h;

With hydrogenchloride; In diethyl ether;

upstream raw materials:

5-(dipropylcarbamoyl)-1-ethyl-1H-pyrazole-3-carboxylic acid

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

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