(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

Base Information

Chemical Name:(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol
CAS No.:388075-42-1
Molecular Formula:C₁₈H₁₉F₅N₂O
Molecular Weight:374.354
Hs Code.:

Synonyms:(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

Suppliers and Price of (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

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Technology Process of (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

There total 1 articles about (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 597564-19-7
1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate

: 388075-42-1
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

Guidance literature:: 1,1-dimethylethyl [(1S,2R)-1-[(3,5-difluorophenyl)methyl]-2-hydroxy-3-({[3-(trifluoromethyl)phenyl]methyl}amino)propyl]-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1106669-02-6
5-(dipropylcarbamoyl)-1-ethyl-1H-pyrazole-3-carboxylic acid

: 388075-42-1
(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol

: 1106668-32-9
N₃-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)-benzyl]amino}propyl]-1-ethyl-N₅,N₅-dipropyl-1H-pyrazole-3,5-dicarboxamide

Guidance literature:: 5-(dipropylcarbamoyl)-1-ethyl-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[3-(trifluoromethyl)-benzyl]amino}butan-2-ol; In N,N-dimethyl-formamide; for 72h;

With hydrogenchloride; In diethyl ether;