O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

Base Information

Chemical Name:O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol
CAS No.:476195-71-8
Molecular Formula:C₂₄H₄₀OSi₃
Molecular Weight:428.837
Hs Code.:

Synonyms:O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

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Technology Process of O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

There total 4 articles about O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1066-54-2
trimethylsilylacetylene

: 476195-70-7
O-tert-butyldimethylsilyl-2-(3,5-dibromophenyl)ethyl alcohol

: 476195-71-8
O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

Guidance literature:: With copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triethylamine; at 65 ℃; for 48h;
DOI:10.1021/jo025723a

Reference yield:

: 75894-93-8
1,3-dibromo-5-(2-hydroxyethyl)benzene

: 476195-71-8
O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 11.70 g / imidazole / CH₂Cl₂ / 2.5 h / 20 °C

2: 82 percent / Pd(dibenzylideneacetone)2; triphenylphosphine; CuI / triethylamine / 48 h / 65 °C

With 1H-imidazole; copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triethylamine; In dichloromethane; 2: Sonogashira coupling;
DOI:10.1021/jo025723a

Reference yield:

: 184769-87-7
3,5-dibromo-4-aminophenethyl alcohol

: 476195-71-8
O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: isoamyl nitrite / dimethylformamide / 0.83 h / 70 °C

2: 11.70 g / imidazole / CH₂Cl₂ / 2.5 h / 20 °C

3: 82 percent / Pd(dibenzylideneacetone)2; triphenylphosphine; CuI / triethylamine / 48 h / 65 °C

With 1H-imidazole; copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; isopentyl nitrite; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 3: Sonogashira coupling;
DOI:10.1021/jo025723a