9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Base Information

Chemical Name:9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
CAS No.:1207455-12-6
Molecular Formula:C₁₆H₁₃N₃O
Molecular Weight:263.299
Hs Code.:

Synonyms:9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Chemical Property of 9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Technology Process of 9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

There total 8 articles about 9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1207455-17-1
9-phenyl-2H-pyrido[4,3 ,2-de]phthalazine-3,8(7H,9H)-dione

: 1207455-12-6
9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: 9-phenyl-2H-pyrido[4,3 ,2-de]phthalazine-3,8(7H,9H)-dione; With diborane; In tetrahydrofuran; 1,4-dioxane; at 95 ℃; for 2h; sealed tube; Inert atmosphere;

With hydrogenchloride; methanol; In tetrahydrofuran; 1,4-dioxane; at 95 ℃; for 0.333333h;

With triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; pH=8;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207455-12-6
9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

3.2: pH 6 - 7

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

4.2: 30 °C

4.3: pH 3 - 4

5.1: sodium sulfate / ethanol / 18 h / 20 °C

6.1: triethylamine / 48 h / Reflux

7.1: hydrazine hydrate / methanol / 2.5 h / 110 °C / microwave irradiation

8.1: borane-THF / 1,4-dioxane / 2.33 h / 95 °C / Sealed tube; Inert atmosphere

8.3: pH 8

With sodium tetrahydroborate; borane-THF; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; sodium sulfate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 65399-18-0
4-nitrophthalide

: 1207455-12-6
9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

2.2: pH 6 - 7

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C

3.2: 30 °C

3.3: pH 3 - 4

4.1: sodium sulfate / ethanol / 18 h / 20 °C

5.1: triethylamine / 48 h / Reflux

6.1: hydrazine hydrate / methanol / 2.5 h / 110 °C / microwave irradiation

7.1: borane-THF / 1,4-dioxane / 2.33 h / 95 °C / Sealed tube; Inert atmosphere

7.3: pH 8

With borane-THF; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; sodium sulfate; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;