Technology Process of 9-phenyl-2H-pyrido[4,3 ,2-de]phthalazine-3,8(7H,9H)-dione
There total 7 articles about 9-phenyl-2H-pyrido[4,3 ,2-de]phthalazine-3,8(7H,9H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
methanol;
at 110 ℃;
for 2.5h;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C
1.2: pH 1
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr
3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C
3.2: pH 6 - 7
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C
4.2: 30 °C
4.3: pH 3 - 4
5.1: sodium sulfate / ethanol / 18 h / 20 °C
6.1: triethylamine / 48 h / Reflux
7.1: hydrazine hydrate / methanol / 2.5 h / 110 °C / microwave irradiation
With
sodium tetrahydroborate; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; sodium sulfate; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr
2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C
2.2: pH 6 - 7
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C
3.2: 30 °C
3.3: pH 3 - 4
4.1: sodium sulfate / ethanol / 18 h / 20 °C
5.1: triethylamine / 48 h / Reflux
6.1: hydrazine hydrate / methanol / 2.5 h / 110 °C / microwave irradiation
With
hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; sodium sulfate; triethylamine;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
