PChd-Gly-OMe

Base Information

• Chemical Name: PChd-Gly-OMe
• CAS No.: 82636-77-9
• Molecular Formula: C₂₃H₃₁NO₃
• Molecular Weight: 369.504
• Mol file: 82636-77-9.mol

Synonyms:PChd-Gly-OMe

Chemical Property of PChd-Gly-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PChd-Gly-OMe

There total 12 articles about PChd-Gly-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

PChd-L-Ile-OH (82636-84-8) → PChd-Gly-OMe (82636-77-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

2: 89 percent / 2 N NaOH / methanol / 2 h / 40 °C

3: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 30 min, 0 deg C; 12 h at room temp.

4: 97 percent / 1 N HCl, H₂ / Pd/10percent on charcoal / methanol / 4 h

5: 81 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH₂Cl₂ / 8 h / anodic oxidation

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198219820608

Reference yield:

PChd-L-Leu-OEt (82636-80-4) → PChd-Gly-OMe (82636-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / 1 N NaOH / methanol / 4 h

2: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

3: 90 percent / 1 N HCl, H₂ / Pd/10percent on charcoal / methanol / 4 h

4: 81 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH₂Cl₂ / 8 h / anodic oxidation

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198219820608

Reference yield:

PChd-L-Ile-OMe (82636-81-5) → PChd-Gly-OMe (82636-77-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 79 percent / 1 N NaOH / methanol / 4 h

2: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

3: 89 percent / 2 N NaOH / methanol / 2 h / 40 °C

4: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 30 min, 0 deg C; 12 h at room temp.

5: 97 percent / 1 N HCl, H₂ / Pd/10percent on charcoal / methanol / 4 h

6: 81 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH₂Cl₂ / 8 h / anodic oxidation

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198219820608

upstream raw materials:

PChd-L-Ile-OH

PChd-L-Ile-OMe

PChd-L-Leu-OEt

PChd-L-Leu-Ala-OMe

Downstream raw materials:

PChd-Gly-OH