Technology Process of L-Leucine,
N-[3,5-bis(1,1-dimethylethyl)-4-oxo-1-phenyl-2,5-cyclohexadien-1-yl]-,
ethyl ester
There total 12 articles about L-Leucine,
N-[3,5-bis(1,1-dimethylethyl)-4-oxo-1-phenyl-2,5-cyclohexadien-1-yl]-,
ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; N,N,N,N-tetraethylammonium tetrafluoroborate;
In
dichloromethane;
for 8h;
anodic oxidation;
DOI:10.1002/jlac.198219820608
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / 1 N HCl, H2 / Pd/10percent on charcoal / methanol / 4 h
2: 89 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH2Cl2 / 8 h / anodic oxidation
With
2,6-dimethylpyridine; hydrogenchloride; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/jlac.198219820608
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH2Cl2; 2.) CH2Cl2, 30 min, 0 deg C; 12 h at room temp.
2: 97 percent / 1 N HCl, H2 / Pd/10percent on charcoal / methanol / 4 h
3: 89 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH2Cl2 / 8 h / anodic oxidation
With
4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/jlac.198219820608
