(-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate

Base Information

• Chemical Name: (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate
• CAS No.: 108793-97-1
• Molecular Formula: C₂₄H₃₆O₃
• Molecular Weight: 372.548
• Mol file: 108793-97-1.mol

Synonyms:(-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate

Chemical Property of (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate

There total 9 articles about (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-8-phenylmenthyl (2S)-2-hydroxy-2-(2-cyclohexenyl)acetate (108793-96-0) → (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate (108793-97-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h;

DOI:10.1016/S0040-4020(01)90590-3

Reference yield: 80.0%

(1R,3R,4S)-8-phenylmenthyl glyoxylate (84312-20-9) + cyclohexylmagnesium bromide (931-50-0) → (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate (108793-97-1)

Guidance literature:

In diethyl ether; at -78 ℃;

DOI:10.1039/c39820000988

Reference yield:

(-)-8-phenylmenthol (65253-04-5) → (-)-8-phenylmenthyl (2S)-2-hydroxy-2-cyclohexylacetate (108793-97-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / p-toluenesulfonic acid monohydrate / benzene / 11 h / Heating

2: 81 percent / AgNO₃ / acetonitrile / 94 h / Ambient temperature

3: 92 percent / sodium acetate trihydrate / dimethylsulfoxide / 1.17 h / Ambient temperature

4: 90 percent / SnCl₄ / CH₂Cl₂ / -78 °C

5: 100 percent / H₂ / Pd/C / methanol / 6 h

With hydrogen; sodium acetate; tin(IV) chloride; toluene-4-sulfonic acid; silver nitrate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)90590-3

upstream raw materials:

(-)-8-phenylmenthyl (2S)-2-hydroxy-2-(2-cyclohexenyl)acetate

(1R,3R,4S)-8-phenylmenthyl glyoxylate

cyclohexylmagnesium bromide

cyclohexene