benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

Base Information

Chemical Name:benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate
CAS No.:401518-84-1
Molecular Formula:C₂₉H₃₆N₂O₄
Molecular Weight:476.616
Hs Code.:

Synonyms:benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

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Technology Process of benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

There total 3 articles about benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 55456-40-1
benzyl 2-aminoisobutyrate

: 401518-83-0
2-(3-cyclopentyloxy-4-methoxyphenyl)-4-oxo-2-(2-oxoethyl)butanenitrile

: 401518-84-1
benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2003.09.087

Reference yield:

: 141333-36-0
4-cyanomethyl-2-cyclopentyloxy-1-methoxybenzene

: 401518-84-1
benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 94 percent / tetrahydrofuran / 1.5 h / -78 °C

2.1: ozone / CH₂Cl₂ / 0.42 h / -78 °C

2.2: Ph₃P / CH₂Cl₂ / 1.5 h / -78 - 20 °C

3.1: 196 mg / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; ozone; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.06.032

Reference yield:

: 401518-81-8
1-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclopen-3-ene-1-carbonitrile

: 401518-84-1
benzyl 2-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / 0.42 h / -78 °C

1.2: Ph₃P / CH₂Cl₂ / 1.5 h / -78 - 20 °C

2.1: 196 mg / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; ozone; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.06.032