2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride

Base Information Edit

Chemical Name:2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride
CAS No.:31677-93-7
Molecular Formula:C₁₃H₁₈ClNO*ClH
Molecular Weight:276.206
Hs Code.:2934.90
Mol file:31677-93-7.mol

2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride

Synonyms:AKOS026750042

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:0.000125mmHg at 25°C
Melting Point:233-234 °C
Boiling Point:334.8 °C at 760 mmHg
Flash Point:156.3 °C
PSA：29.10000
Density:==
LogP:4.49220
Storage Temp.:Desiccate at RT
Solubility.:ethanol: 193 mg/mL solutions may be stored for several days
Water Solubility.:Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:275.0843696
Heavy Atom Count:17
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi,T,F
Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:[H+].CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.[Cl-]
Uses Bupropion hydrochloride is indicated for the treatment of MDD. Bupropion hydrochloride SR (Zyban) is indicated as an aid to smoking cessation treatment.
Drug interactions Relatively few data are available on interactions of bupropion hydrochloride with other drugs. Increased adverse experiences were reported when the drug was administered concomitantly with l-dopa. MAOIs may increase the acute toxicity of bupropion. Although bupropion is not metabolized by the CYP2D6 enzyme, the drug and its metabolite, morpholinol, inhibit this enzyme in vitro. Therefore, extreme caution should be exercised when coadministering any drug metabolized by that enzyme, and initial dosage of the drug should be as low as possible.
Therapeutic Function Antidepressant; Smoking cessation aid

Technology Process of 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride

There total 14 articles about 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 34841-39-9,34911-55-2,144445-75-0,144445-76-1
bupropion

: 31677-93-7
BUPROPION HYDROCHLORIDE

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 0 - 20 ℃; for 1h; pH=2;

Reference yield: 80.0%

: (R) bupropion trifluoroacetate

: 849797-12-2,31677-93-7
(R)-Bupropion hydrochloride

Guidance literature:: (R) bupropion trifluoroacetate; With sodium hydrogencarbonate; In water; ethyl acetate;

With hydrogenchloride; In hexane; isopropyl alcohol;