(2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide

Base Information

• Chemical Name: (2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide
• CAS No.: 1147745-41-2
• Molecular Formula: C₃₇H₃₅F₃N₂O₅
• Molecular Weight: 644.691

Synonyms:(2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide

Chemical Property of (2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide

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Technology Process of (2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide

There total 1 articles about (2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(3S,11bS)-3-amino-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one (949463-53-0) + R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → (2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide (1147745-41-2)

Guidance literature:

With dmap; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In hexane; dichloromethane; at 20 ℃; for 3h;

Reference yield: 84.0%

(2'R)-N-((3S,11bS)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide (1147745-41-2) → (2'R)-N-((3S,11bS)-9,11-dihydroxy-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 12h; under 760.051 Torr;

upstream raw materials:

(3S,11bS)-3-amino-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

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