(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

Base Information

Chemical Name:(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester
CAS No.:123993-22-6
Molecular Formula:C₂₅H₂₉NO₆
Molecular Weight:439.508
Hs Code.:

Synonyms:(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

There total 2 articles about (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 82101-74-4
methyl (E)-3-(tributylstannyl)acrylate

: 123993-20-4
N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester

: 123993-22-6
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

Guidance literature:: With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 95 ℃; for 1.5h;
DOI:10.1021/jo00290a021

Reference yield:

: 19391-35-6
N-tert-butoxycarbonyl-L-tyrosine benzyl ester

: 123993-22-6
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) up to RT, over 1 h

2: 65 percent / LiCl / bis(triphenylphosphine)palladium dichloride / dimethylformamide / 1.5 h / 95 °C

With triethylamine; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a021