123993-20-4

Upstream product

• 19391-35-6 N-tert-butoxycarbonyl-L-tyrosine benzyl ester 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 100-39-0 benzyl bromide 
• 3978-80-1 Boc-Tyr-OH 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 456-64-4 phenyl trifluoromethanesulfonamide 

Downstream Products

• 154483-80-4 N^α-Boc-4-(dimethoxyphosphinyl)-L-phenylalanine benzyl ester 
• 150618-06-7 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester 
• 123993-22-6 (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxo-1-propenyl)benzenepropanoic acid phenylmethyl ester 
• 123993-25-9 (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid phenylmethylester 
• 150618-07-8 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 
• 244757-65-1 (S)-4-[4-((S)-2-tert-Butoxycarbonylamino-2-carboxy-ethyl)-benzoylamino]-4-(6-{(S)-2-[4-((S)-2-tert-butoxycarbonylamino-2-carboxy-ethyl)-benzoylamino]-4-methoxycarbonyl-butyrylamino}-pyridin-2-ylcarbamoyl)-butyric acid methyl ester 
• 244757-64-0 (S)-4-[4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoylamino]-4-(6-{(S)-2-[4-((S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoylamino]-4-methoxycarbonyl-butyrylamino}-pyridin-2-ylcarbamoyl)-butyric acid methyl ester 
• 153037-45-7 benzyl (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-phenylphenyl)propanoate 
• 123993-24-8 (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(3-methoxy-3-oxopropyl)benzenepropanoic acid 
• 367266-82-8 (S)-4-((S)-2-Acetylamino-3-{4-[2-methoxycarbonyl-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-phenyl}-propionylamino)-4-[(S)-3-tert-butoxycarbonyl-1-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-propylcarbamoyl]-butyric acid tert-butyl ester 
• 367266-74-8 (S)-4-((S)-2-Acetylamino-3-{4-[2-methoxycarbonyl-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-phenyl}-propionylamino)-4-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-butyric acid benzyl ester 
• 367266-81-7 (S)-4-{(S)-2-Acetylamino-3-[4-(2-methoxycarbonyl-2-oxo-acetyl)-phenyl]-propionylamino}-4-[(S)-3-tert-butoxycarbonyl-1-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-propylcarbamoyl]-butyric acid tert-butyl ester 
• 367266-75-9 (S)-4-{(S)-2-Acetylamino-3-[4-(2-methoxycarbonyl-2-oxo-acetyl)-phenyl]-propionylamino}-4-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-butyric acid benzyl ester 
• 367266-72-6 3-[4-(2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-phenyl]-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING

Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.

1,3-dialkylurea derivatives having a hydroxyl group

The present invention related to compounds represented by the following formula (I) and salts thereof, STR1 wherein R1 and R4 each represents a carboxyl or a carboxyl which is converted into an ester, an amide or hydroxamic acid; Rs

1,3-DIALKYLUREA DERIVATIVE

The present invention relates to compounds represented by the formula [I] and salts thereof, wherein R 1 and R 5 each represents carboxyl, phosphonic or a derivative thereof; R 2 represents hydrogen, lower alkyl, (substituted) phenyl lower alkyl, lower al

A synthetic receptor for the Cbz-L-Ala-L-Ala-OH dipeptide sequence

A novel bowl-shaped macrobicyclic receptor has been prepared and is a particularly strong and selective receptor for Cbz-L-Ala-L-Ala-OH(-ΔG(ass) = 25 kJ mol-1 at 293 K in CDCL3).

New- Nα-Guanidinobenzoyl Derivatives of Hirudin-54-65 Containing Stabilized Carboxyl or Phosphoryl Groups on the Side Chain of Phenylalanine-63

We report on the synthesis and pharmacological properties of a new series of thrombin inhibitors derived from hirudin carboxyl-terminal fragments.Two (arylphosphono)phenylalanines, p-PO3H2-L-Phe1 and m-PO3H2-L-Tyr, and one (carboxymethyl)phenylalanine, p-CH2COOH-L-Phe, were prepared and incorporated into position 63 of the modified hirudin's C-terminal dodecapeptide using the Fmoc solid-phase synthesis strategy.Substitution by any one of the residues led to very active analogs which doubled the thrombin time at low micromolar concentration (Ctt2) in vitro (1 μM 2 3 μM) and potently increased the activated partial thromboplastin time (APTT) ex vivo.These compounds displayed a higher potency in vitro and a longer duration of action in vivo than both the corresponding sulfated or phosphorylated tyrosine counterparts.