ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

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Chemical Name:ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate
CAS No.:862814-44-6
Molecular Formula:C₂₆H₃₀N₄O₉S₂
Molecular Weight:606.678
Hs Code.:

Synonyms:ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

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Chemical Property of ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

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Technology Process of ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

There total 3 articles about ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 380897-71-2
(3-acetoxy-2-O-benzoyl-1-propoxy)methyl bromide

: 862784-32-5
ethyl α-[6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thioacetate

: 862814-44-6
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

Guidance literature:: With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1080/15257770701296952

Reference yield:

: 5334-32-7
1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione

: 862814-44-6
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / aq. sodium hydroxide / 3 h / 20 °C

2: 76 percent / 18-crown-6; potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C

With sodium hydroxide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1080/15257770701296952

Reference yield:

: 24521-76-4
6-thioxo-1,5,6,7-tetrahydropyrazolo<3,4-d>pyrimidin-4-one

: 862814-44-6
ethyl α-[1-(3-acetoxy-2-O-benzoyl-1-propoxy)methyl-6-carboethoxymethylthio-1H-pyrazolo[3,4-d]pyrimidin-4-ylthio]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: P₂S₅; pyridine

2: aq. NaOH / 20 °C

3: t-BuOK; 18-crown-6 / tetrahydrofuran

With pyridine; sodium hydroxide; tetraphosphorus decasulfide; 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1081/NCN-120022697