4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

Base Information

Chemical Name:4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone
CAS No.:281192-58-3
Molecular Formula:C₁₆H₂₃F₃N₂O₂
Molecular Weight:332.366
Hs Code.:

Synonyms:4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

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Chemical Property of 4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

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Technology Process of 4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

There total 5 articles about 4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 281192-46-9
1-[(1R)-1-(methoxymethyl)propyl]-1-(2,2,2-trifluoroethyl)hydrazine

: 281192-58-3
4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

Guidance literature:: With toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1016/S0957-4166(00)00044-6

Reference yield:

: 57883-06-4
(R)-1-(methoxymethyl)propylamine

: 281192-58-3
4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

Guidance literature:: Multi-step reaction with 5 steps

1: 82.5 percent / Na₂CO₃ / diethyl ether / 3 h / -10 - 20 °C

2: 80.9 percent / LiAlH₄ / diethyl ether / 11 h

3: 91.5 percent / sodium nitrite; aq. hydrochloric acid / 17 h / 20 °C

4: 70 percent / LiAlH₄ / diethyl ether / 6 h / 20 °C

5: 75.3 percent / TsOH / toluene / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sodium carbonate; toluene-4-sulfonic acid; sodium nitrite; In diethyl ether; toluene; 1: Acylation / 2: Reduction / 3: Nitrosation / 4: Reduction / 5: Condensation;
DOI:10.1016/S0957-4166(00)00044-6

Reference yield:

: 281192-43-6
(1R)-N-[1-(methoxymethyl)propyl]trifluoroacetamide

: 281192-58-3
4-methoxyacetophenone-N-[(1R)-1-(methoxymethyl)propyl]-N-(2,2,2-trifluoroethyl)hydrazone

Guidance literature:: Multi-step reaction with 4 steps

1: 80.9 percent / LiAlH₄ / diethyl ether / 11 h

2: 91.5 percent / sodium nitrite; aq. hydrochloric acid / 17 h / 20 °C

3: 70 percent / LiAlH₄ / diethyl ether / 6 h / 20 °C

4: 75.3 percent / TsOH / toluene / Heating

With hydrogenchloride; lithium aluminium tetrahydride; toluene-4-sulfonic acid; sodium nitrite; In diethyl ether; toluene; 1: Reduction / 2: Nitrosation / 3: Reduction / 4: Condensation;
DOI:10.1016/S0957-4166(00)00044-6