2,3-Diamino-6-methoxypyridine

Base Information

• Chemical Name: 2,3-Diamino-6-methoxypyridine
• CAS No.: 28020-38-4
• Molecular Formula: C6H9N3O
• Molecular Weight: 139.157
• Hs Code.: 2933399090
• European Community (EC) Number: 858-385-3
• UNII: VGV76K138F
• DSSTox Substance ID: DTXSID80388570
• Nikkaji Number: J313.756B
• Wikidata: Q27291821
• Mol file: 28020-38-4.mol

Synonyms:2,3-Diamino-6-methoxypyridine;6-methoxypyridine-2,3-diamine;28020-38-4;2,3-Pyridinediamine, 6-methoxy-;6-METHOXY-2,3-PYRIDINEDIAMINE;6-METHOXY-2,3-DIAMINOPYRIDINE;Pyridine, 2,3-diamino-6-methoxy-;UNII-VGV76K138F;VGV76K138F;2,3-Diamino-6-methoxypyridine HCl;SCHEMBL126903;6-methoxy-pyridine-2,3-diamine;DTXSID80388570;WEPOCTWSRWLQLL-UHFFFAOYSA-N;6-(Methyloxy)-2,3-pyridinediamine;MFCD06658229;AKOS006282278;AB25773;AC-8147;CCG-302519;SB53083;BS-32213;2,3-Diamino-6-methoxypyridinedihydrochloride;A5363;AM20051034;CS-0082305;FT-0601490;EN300-92115;J-518864;Q27291821;Z1198169423

Chemical Property of 2,3-Diamino-6-methoxypyridine

Chemical Property:

• Vapor Pressure: 4.13E-05mmHg at 25°C
• Melting Point: 168-170 °C
• Boiling Point: 321.7 °C at 760 mmHg
• PKA: 4.55±0.50(Predicted)
• Flash Point: 148.3 °C
• PSA: 74.16000
• Density: 1.251 g/cm³
• LogP: 3.02100
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 139.074561919
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxypyridine-2,3-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)N)N

Technology Process of 2,3-Diamino-6-methoxypyridine

There total 7 articles about 2,3-Diamino-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methoxy-3-nitropyridin-2-amine (73896-36-3) → 2,3-diamino-6-methoxypyridine (28020-38-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h;

Reference yield: 92.0%

6-methoxypyridine-2,3-diamine dihydrochloride (1159824-73-3,94166-62-8) → 2,3-diamino-6-methoxypyridine (28020-38-4)

Guidance literature:

With ammonia; In water; at 15 ℃; pH=7 - 8;

Reference yield: 45.6%

→ 2,3-diamino-6-methoxypyridine (28020-38-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 24h;

upstream raw materials:

6-methoxy-3-nitropyridin-2-amine

2-amino-6-chloro-3-nitropyridine

6-methoxypyridine-2,3-diamine dihydrochloride

2,6-dicholoro-3-nitropyridine

Downstream raw materials:

phenylmethyl 6-(methyloxy)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-1(2H)-carboxylate

4-(3-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)-6-(methyloxy)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one

6-(methyloxy)-4-(3-{[(phenylmethyl)oxy]amino}-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one

6-(methyloxy)-4-(3-{[(phenylmethyl)oxy]amino}-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)pyrido[2,3-b]pyrazin-3(4H)-one