(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

Base Information

Chemical Name:(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride
CAS No.:1609554-54-2
Molecular Formula:C₁₅H₁₈N₂O₄S*ClH
Molecular Weight:358.846
Hs Code.:

Synonyms:(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

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Technology Process of (S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

There total 2 articles about (S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (S)-tert-butyl (1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)carbamate

: 1609554-54-2
(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 127132-38-1
N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine

: 1609554-54-2
(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran; dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield: 76.0%

: 1609554-60-0
(2S)-2-((2S,4S)-4-allyl-1-((2S)-2-((2S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(naphthalen-2-yl)propanoic acid

: 1609554-54-2
(S)-2-amino-N-(cyclopropylsulfonyl)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamide hydrochloride

: 1609554-61-1
tert-butyl ((2S)-1-(((2S)-1-((2S,4S)-4-allyl-2-(((2S)-1-(((2S)-1-(cyclopropanesulfonamido)-1-oxo-3-(4-(prop-2-yn-1-yloxy)phenyl)propan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;