3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Base Information

Chemical Name:3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one
CAS No.:912295-27-3
Molecular Formula:C₁₄H₁₇ClO₃S
Molecular Weight:300.806
Hs Code.:

Synonyms:3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

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Chemical Property of 3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

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Technology Process of 3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

There total 1 articles about 3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 184435-75-4
(5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one

: 912295-27-3
3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

: 3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: (5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one; With lithium hexamethyldisilazane; In toluene; for 0.5h; cooling;

(S)-epichlorohydrin; With triethyl borane; In toluene; for 8h;
DOI:10.1021/ol061847o

Reference yield: 85.0%

: 912295-27-3
3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

: 912295-37-5
5-methyl-3-oxiranylmethyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;
DOI:10.1021/ol061847o

Reference yield:

: 912295-27-3
3-(3-chloro-2-hydroxy-propyl)-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

: 912295-36-4
3-{13-benzyloxy-13-[5'-(1-benzyloxyundecyl)octahydro-[2,2']bifuranyl-5-yl]-2-hydroxytridecyl}-5-methyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / NaH; Bu₄NI / dimethylformamide / 0.08 h / 0 °C

2.1: 86 percent / m-CPBA / CH₂Cl₂ / 0.75 h / cooling

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

3.2: 65 percent / BF₃*Et₂O / tetrahydrofuran / 3 h

4.1: 95 percent / p-toluenesulfonyl hydrazide; NaOAc / 1,2-dimethoxy-ethane; H₂O / 5 h / Heating

With n-butyllithium; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol061847o