3-(4-bromobenzoyl)-2-methylenepropionic acid

Base Information

• Chemical Name: 3-(4-bromobenzoyl)-2-methylenepropionic acid
• CAS No.: 101973-98-2
• Molecular Formula: C₁₁H₉BrO₃
• Molecular Weight: 269.095
• Mol file: 101973-98-2.mol

Synonyms:3-(4-bromobenzoyl)-2-methylenepropionic acid

Chemical Property of 3-(4-bromobenzoyl)-2-methylenepropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(4-bromobenzoyl)-2-methylenepropionic acid

There total 2 articles about 3-(4-bromobenzoyl)-2-methylenepropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.1%

bromobenzene (108-86-1,52753-63-6) + itaconic acid anhydride (2170-03-8) → 3-(4-bromobenzoyl)-2-methylenepropionic acid (101973-98-2)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane;

DOI:10.1248/cpb.36.2050

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 3-(4-bromobenzoyl)-2-methylenepropionic acid (101973-98-2)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja01116a045

Reference yield: 91.0%

3-(4-bromobenzoyl)-2-methylenepropionic acid (101973-98-2) → 4-(4-bromophenyl)-2-methyl-4-oxobutanoic acid (75382-10-4)

Guidance literature:

With hydrogen; palladium diacetate; zinc trifluoromethanesulfonate; 1,4-di(diphenylphosphino)-butane; In 1,2-dichloro-ethane; at 60 ℃; for 30h; under 750.075 Torr; chemoselective reaction; Autoclave;

DOI:10.1039/c9ob00005d

upstream raw materials:

bromobenzene

itaconic acid anhydride

Downstream raw materials:

4-(4-bromophenyl)-2-methyl-4-oxobutanoic acid

3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid

3-(4-bromobenzoyl)-2-propionylthiomethylpropionic acid

2-acetylthiomethyl-4-(4-bromophenyl)-4-oxobutanoic acid