3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid

Base Information

• Chemical Name: 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid
• CAS No.: 101973-87-9
• Molecular Formula: C₁₈H₁₅BrO₄S
• Molecular Weight: 407.285
• Mol file: 101973-87-9.mol

Synonyms:3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid

Chemical Property of 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid

There total 3 articles about 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.8%

thiobenzoic acid (98-91-9) + 3-(4-bromobenzoyl)-2-methylenepropionic acid (101973-98-2) → 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid (101973-87-9)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 30 ℃; for 2.5h;

DOI:10.1248/cpb.36.2050

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid (101973-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.1 percent / AlCl₃ / 1,2-dichloro-ethane

2: 35.8 percent / potassium carbonate / dimethylformamide; H₂O / 2.5 h / 30 °C

With aluminium trichloride; potassium carbonate; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.2050

Reference yield:

itaconic acid anhydride (2170-03-8) → 3-(4-bromobenzoyl)-2-benzoylthiomethylpropionic acid (101973-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.1 percent / AlCl₃ / 1,2-dichloro-ethane

2: 35.8 percent / potassium carbonate / dimethylformamide; H₂O / 2.5 h / 30 °C

With aluminium trichloride; potassium carbonate; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.2050

upstream raw materials:

thiobenzoic acid

3-(4-bromobenzoyl)-2-methylenepropionic acid

bromobenzene

itaconic acid anhydride