2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Base Information

• Chemical Name: 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide
• CAS No.: 1629888-41-0
• Molecular Formula: C₁₇H₁₀F₃N₃O₃S
• Molecular Weight: 393.346

Synonyms:2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Chemical Property of 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Chemical Property:

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Technology Process of 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

There total 3 articles about 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide (1629888-39-6) + 2,3,4-trifluoro-benzoyl chloride (157373-08-5) → 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide (1629888-41-0)

Guidance literature:

1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide; With triethylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h;

2,3,4-trifluoro-benzoyl chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.2174/1570180811666131230235157

Reference yield:

N-Methylanthranilic acid (119-68-6) → 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide (1629888-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Alkaline conditions

2.1: hydrogenchloride / water / 0.5 h / Reflux

2.2: 4 h / Reflux

3.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 5 °C

3.2: 20 °C

With hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.2174/1570180811666131230235157

Reference yield:

glycosmicine (604-50-2) → 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide (1629888-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 0.5 h / Reflux

1.2: 4 h / Reflux

2.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 5 °C

2.2: 20 °C

With hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.2174/1570180811666131230235157

upstream raw materials:

N-Methylanthranilic acid

1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide

2,3,4-trifluoro-benzoyl chloride

glycosmicine

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