157373-08-5

Usage

Uses

Used in Pharmaceutical Industry:
2,3,4-Trifluorobenzoyl chloride is used as a key reagent for the preparation of Levofloxacin, a widely prescribed antibiotic belonging to the fluoroquinolone class. Levofloxacin is effective against a broad spectrum of bacteria, making it a valuable component in treating various bacterial infections.
The use of 2,3,4-trifluorobenzoyl chloride in the synthesis of Levofloxacin highlights its importance in the pharmaceutical industry, as it contributes to the development of life-saving medications. Its unique chemical properties allow for specific reactions that facilitate the production of the desired antibiotic, showcasing its significance in the field of medicinal chemistry.

InChI:InChI=1/C7H2ClF3O/c8-7(12)3-1-2-4(9)6(11)5(3)10/h1-2H

Upstream product

• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 157766-29-5 2,3,4-trifluoro-benzotrichloride 

Downstream Products

• 740817-48-5 3-methyl-5-(2,3,4-trifluorophenyl)-1,2,4-oxadiazole 
• 100936-90-1 diethyl (2,3,4-trifluorobenzoyl)malonate 
• 1597407-58-3 {3-hydroxy-3-[(S)-1-((S)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-azetidin-1-yl}-(2,3,4-trifluoro-phenyl)-methanone 
• 1629888-41-0 2,3,4-trifluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide 
• 1369665-02-0 (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate 
• 934660-93-2 [14C]-GDC-0973 
• 1401998-80-8 3-fluoro-2,4-dihydroxybenzaldehyde 
• 143879-80-5 2,3,4-trifluorobenzonitrile 

Relevant academic research and scientific papers

Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening

As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these a new coumarin-based fluorophore, Jericho Blue, was selected as having optimal characteristics for our screen. A reliable method for the challenging synthesis of coumarin glycosides of α-GalNAc was then developed and demonstrated with nine examples. The α-GalNAc glycoside of Jericho Blue prepared in this way was shown to function well under screening conditions.

CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE

This disclosure relates to the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-l-yl]-methanone. The disclosure also relates to pharmaceutical compositions comprising the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-l-yl]-methanone. The disclosure also relates to methods of treating cancers comprising administering to a patient in need thereof the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone.

NOVEL PROCESS FOR MAKING COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Process for the preparation of polyhalogenated benzotrifluorides, benzotrichlorides and benzoyl chlorides and new trihalogenobenzotrichlorides and -benzoyl chlorides

Polyhalogenated benzotrifluorides can be reacted with chlorides from the series of Friedel-Crafts catalysts to give the corresponding benzotrichlorides, which can be hydrolysed by water in the presence of iron(III) chloride to give the corresponding benzoyl chlorides. These are suitable as intermediate products for the preparation of active compounds for medicaments and feed additives.