N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester

Base Information

• Chemical Name: N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester
• CAS No.: 132018-90-7
• Molecular Formula: C₂₂H₃₂N₂O₁₀
• Molecular Weight: 484.503
• Mol file: 132018-90-7.mol

Synonyms:N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester

Chemical Property of N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester

There total 1 articles about N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-nitroveratryl alcohol (1016-58-6) + N-tert-butoxycarbonyl aspartic acid tert-butyl ester (34582-32-6) → N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester (132018-90-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/ja00007a055

Reference yield:

N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester (132018-90-7) → (S)-2-Amino-succinic acid 4-(4,5-dimethoxy-2-nitro-benzyl) ester

Guidance literature:

With trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/ja00007a055

Reference yield:

N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester (132018-90-7) → 5'-phospho-2'-deoxycytidylyl(3'-5')-2'-O-adenosine (132018-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: CF₃CO₂H, p-dimethoxybenzene / CH₂Cl₂ / 5 h / Ambient temperature

2: Et₃N / acetonitrile / Ambient temperature

3: 1.) Dowex 1x8-200 ion-exchange beads (Bu₄N-form), Bu₄NOH / 1.) H₂O, 2.) DMF, RT, 2.5 h

With Dowex 1x8-200 ion-exchange beads (Bu₄N-form); tetra(n-butyl)ammonium hydroxide; triethylamine; trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; acetonitrile;

DOI:10.1021/ja00007a055

upstream raw materials:

6-nitroveratryl alcohol

N-tert-butoxycarbonyl aspartic acid tert-butyl ester

Downstream raw materials:

5'-phospho-2'-deoxycytidylyl(3'-5')-2'-O-adenosine

5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine

N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester