N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester

Base Information

• Chemical Name: N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester
• CAS No.: 132018-87-2
• Molecular Formula: C₂₅H₂₆N₄O₁₄
• Molecular Weight: 606.5
• Mol file: 132018-87-2.mol

Synonyms:N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester

Chemical Property of N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester

There total 3 articles about N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-nitroveratryl alcohol (1016-58-6) → N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester (132018-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / dicyclohexylcarbodiimide (DCC), (dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: CF₃CO₂H, p-dimethoxybenzene / CH₂Cl₂ / 5 h / Ambient temperature

3: Et₃N / acetonitrile / Ambient temperature

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; acetonitrile;

DOI:10.1021/ja00007a055

Reference yield:

N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester (132018-90-7) → N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester (132018-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃CO₂H, p-dimethoxybenzene / CH₂Cl₂ / 5 h / Ambient temperature

2: Et₃N / acetonitrile / Ambient temperature

With triethylamine; trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; acetonitrile;

DOI:10.1021/ja00007a055

Reference yield:

(S)-2-Amino-succinic acid 4-(4,5-dimethoxy-2-nitro-benzyl) ester + chloroacetonitrile (107-14-2) → N-NVOC-L-aspartic acid α-cyanomethyl β-6-nitroveratryl diester (132018-87-2)

Guidance literature:

With triethylamine; In acetonitrile; Yield given; Ambient temperature;

DOI:10.1021/ja00007a055

upstream raw materials:

chloroacetonitrile

6-nitroveratryl alcohol

N-Boc-L-aspartic acid α-tert-butyl β-6-nitroveratryl diester

Downstream raw materials:

5'-phospho-2'-deoxycytidylyl(3'-5')-2'-O-adenosine

5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine