Technology Process of 3-{[(3-methyl-5-morpholin-4-yl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid
There total 6 articles about 3-{[(3-methyl-5-morpholin-4-yl-1-benzothiophen-2-yl)sulfonyl]amino}benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: polyphosphoric acid / chlorobenzene / 24 h / Reflux
2: chlorosulfonic acid / chloroform / -5 - 0 °C
3: pyridine / dichloromethane / 20 °C
4: caesium carbonate; johnphos / palladium diacetate / 1,4-dioxane / 20 h / 110 °C
5: water; lithium hydroxide / tetrahydrofuran
With
pyridine; chlorosulfonic acid; water; caesium carbonate; lithium hydroxide; johnphos;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; chlorobenzene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / acetone / Reflux
2: polyphosphoric acid / chlorobenzene / 24 h / Reflux
3: chlorosulfonic acid / chloroform / -5 - 0 °C
4: pyridine / dichloromethane / 20 °C
5: caesium carbonate; johnphos / palladium diacetate / 1,4-dioxane / 20 h / 110 °C
6: water; lithium hydroxide / tetrahydrofuran
With
pyridine; chlorosulfonic acid; water; potassium carbonate; caesium carbonate; lithium hydroxide; johnphos;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; chlorobenzene; acetone;