1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

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Chemical Name:1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea
CAS No.:1271240-87-9
Molecular Formula:C₃₈H₄₇N₃O₈
Molecular Weight:673.806
Hs Code.:

Synonyms:1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

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Chemical Property of 1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

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Technology Process of 1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

There total 12 articles about 1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1309689-50-6
(E)-2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate

: 1271240-78-8
(3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidine

: 1271240-87-9
1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

Guidance literature:: In 1,4-dioxane; for 0.5h;
DOI:10.1016/j.tet.2010.12.029

Reference yield:

: 1271240-62-0
(3R,5R)-1-N-tert-butyloxycarbonyl-3,5-dihydroxypiperidine

: 1271240-87-9
1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 7 h / Inert atmosphere

2: dmap / dichloromethane / 1 h

3: sodium azide / N,N-dimethyl-formamide / 12 h / 90 °C

4: 10% palladium on activated charcoal; hydrogen / ethanol / 760.05 Torr

5: 1,4-dioxane / 0.5 h

With pyridine; dmap; sodium azide; 10% palladium on activated charcoal; hydrogen; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2010.12.029

Reference yield:

: 1271240-73-3
(3S,5R)-3-azido-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidine

: 1271240-87-9
1-((3S,5R)-3-amino-1-N-tert-butyloxycarbonyl-5-dimethoxytrityloxypiperidin-3-yl)-3-((E)-3-ethoxy-2-methylacryloyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: 10% palladium on activated charcoal; hydrogen / ethanol / 760.05 Torr

2: 1,4-dioxane / 0.5 h

With 10% palladium on activated charcoal; hydrogen; In 1,4-dioxane; ethanol;
DOI:10.1016/j.tet.2010.12.029