(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Base Information

Chemical Name:(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one
CAS No.:1355959-69-1
Molecular Formula:C₁₉H₁₆FN₃O₅
Molecular Weight:385.352
Hs Code.:

Synonyms:(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Suppliers and Price of (Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

There total 4 articles about (Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1355959-47-5
(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

: 1355959-69-1
(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Guidance literature:: (Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one; With boron tribromide; In dichloromethane; at 0 - 20 ℃;

With water; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmc.2011.11.014

Reference yield:

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 1355959-69-1
(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / water; acetone / 20 °C

2.1: potassium carbonate / ethanol; acetonitrile / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

3.2: 0 °C / Reflux

4.1: boron tribromide / dichloromethane / 0 - 20 °C

4.2: 0 °C

With sodium azide; boron tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; acetonitrile; mineral oil; 3.2: Claisen condensation;
DOI:10.1016/j.bmc.2011.11.014

Reference yield:

: 1267944-18-2
C₁₂H₁₂FN₃O

: 1355959-69-1
(Z)-1-(1-(3-fluorobenzyl)-5-methyl-1H-1,2,3-triazol-4-yl)-3-hydroxy-3-(3,4,5-trihydroxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

1.2: 0 °C / Reflux

2.1: boron tribromide / dichloromethane / 0 - 20 °C

2.2: 0 °C

With boron tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil; 1.2: Claisen condensation;
DOI:10.1016/j.bmc.2011.11.014