N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

Base Information

Chemical Name:N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine
CAS No.:619334-40-6
Molecular Formula:C₁₇H₁₅N₅O₂S
Molecular Weight:353.404
Hs Code.:

Synonyms:N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

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Chemical Property of N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

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Technology Process of N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

There total 4 articles about N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 619334-38-2
6-[5-(4-cyano-phenyl)-thiophen-2-yl]-nicotinonitrile

: 619334-40-6
N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

Guidance literature:: With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/jm0302602

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 619334-40-6
N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / tetrakis(triphenylphosphine)palladium / dioxane / 24 h / 100 - 110 °C

2: 95 percent / N-bromosuccinimide / dimethylformamide / 20 °C

3: 77.7 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine) palladium / toluene; methanol / 24 h / 80 °C

4: 97 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: Stille coupling / 3: Suzuki coupling;
DOI:10.1021/jm0302602

Reference yield:

: 619334-36-0
6-(thiophen-2-yl)nicotinonitrile

: 619334-40-6
N-hydroxy-6-{5-[4-(N-hydroxycarbamimidoyl)-phenyl]-thiophen-2-yl}-nicotinamidine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / N-bromosuccinimide / dimethylformamide / 20 °C

2: 77.7 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine) palladium / toluene; methanol / 24 h / 80 °C

3: 97 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1021/jm0302602