Technology Process of tert-butyl 2-phenyl-3,4,7,8-tetrahydro-1,2-diazocine-1(2H)-carboxylate
There total 4 articles about tert-butyl 2-phenyl-3,4,7,8-tetrahydro-1,2-diazocine-1(2H)-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.11.091
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydroxide;
In
toluene;
for 24h;
Inert atmosphere;
Reflux;
DOI:10.1007/s10593-018-2308-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - -40 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: potassium carbonate; sodium hydroxide / toluene / 20 °C
3.1: Grubbs catalyst first generation / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
Grubbs catalyst first generation; n-butyllithium; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2011.11.091
