C₂₄H₂₆F₃NO₄S

Base Information

• Chemical Name: C₂₄H₂₆F₃NO₄S
• CAS No.: 1208110-27-3
• Molecular Formula: C₂₄H₂₆F₃NO₄S
• Molecular Weight: 481.536
• Mol file: 1208110-27-3.mol

Synonyms:C₂₄H₂₆F₃NO₄S

Chemical Property of C₂₄H₂₆F₃NO₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₆F₃NO₄S

There total 17 articles about C₂₄H₂₆F₃NO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trifluoromethylsulfonic anhydride (358-23-6) + (2RS)-6-hydroxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one (1208110-26-2) → C24H26F3NO4S (1208110-27-3)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.bmc.2017.05.012

Reference yield:

(2RS)-1-benzoylpiperidine-2-carbonitrile (71413-04-2) → C24H26F3NO4S (1208110-27-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / toluene / 4 h / 20 °C

2.2: 18 h / 120 °C

3.1: sodium hydride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 9 h / 120 °C

3.3: Cooling with ice

4.1: hydrogen bromide / 36 h / Reflux

5.1: pyridine / 14 h / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogen bromide; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2017.05.012

Reference yield:

N-benzoyl-2-piperidinecarboxylic acid (78348-46-6) → C24H26F3NO4S (1208110-27-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / -20 - -15 °C

1.2: 3 h / 20 °C

2.1: trichlorophosphate; pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 27 h / 0 - 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere

4.1: trimethylsilyl trifluoromethanesulfonate / 18 h / 20 °C

4.2: 48 h / 130 °C

5.1: sodium hydride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 9 h / 120 °C

5.3: Cooling with ice

6.1: hydrogen bromide / 36 h / Reflux

7.1: pyridine / 14 h / 0 - 20 °C / Inert atmosphere

With pyridine; trimethylsilyl trifluoromethanesulfonate; hydrogen bromide; chloroformic acid ethyl ester; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2017.05.012

upstream raw materials:

(2RS)-1-benzoylpiperidine-2-carbonitrile

N-benzoyl-2-piperidinecarboxylic acid

6-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride

trifluoromethylsulfonic anhydride

Downstream raw materials:

(2RS)-N-{1'-[2-(2-methylphenyl)ethyl]-1-oxo-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-6-yl}acetamide

(2RS)-1'-[2-(2-methylphenyl)ethyl]-6-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride

(2RS)-1'-[2-(2-methylphenyl)ethyl]-1-oxo-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidine]-6-carbonitrile hydrochloride

Refernces