4-Cyclopentylmorpholine

Base Information

• Chemical Name: 4-Cyclopentylmorpholine
• CAS No.: 39198-78-2
• Molecular Formula: C9H17NO
• Molecular Weight: 155.23738
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80540515
• Nikkaji Number: J1.202.840G
• Wikidata: Q82416551
• Mol file: 39198-78-2.mol

Synonyms:4-cyclopentylmorpholine;39198-78-2;Morpholine, 4-cyclopentyl-;morpholinocyclopentane;N-cyclopentylmorpholine;1-morpholinocyclopentane;SCHEMBL1827648;DTXSID80540515;WQSGOPRYLPXKNG-UHFFFAOYSA-N;MFCD09263683;AKOS002288641;AS-75642;SY108451;A6566;CS-0199120;D97822

Chemical Property of 4-Cyclopentylmorpholine

Chemical Property:

• Boiling Point: 217.953 °C at 760 mmHg
• Flash Point: 62.628 °C
• PSA: 12.47000
• Density: 1.029 g/cm³
• LogP: 1.19910
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 155.131014166
• Heavy Atom Count: 11
• Complexity: 115

Purity/Quality:

99% ^*data from raw suppliers

4-Cyclopentylmorpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)N2CCOCC2

Technology Process of 4-Cyclopentylmorpholine

There total 6 articles about 4-Cyclopentylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(N-morpholino)cyclopent-1-ene (936-52-7) → N-cyclopentylmorpholine (39198-78-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 0.333333h; Ambient temperature;

DOI:10.1021/jo960057x

Reference yield: 73.0%

C24H38N2OS2 (109072-78-8) → N-cyclopentylmorpholine (39198-78-2) + 2,4-di-tert-butyl-6-methylaniline (35532-73-1)

Guidance literature:

With hydrogen; nickel; In ethanol; ethyl acetate; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(00)85399-X

Reference yield: 72.0%

1-(N-morpholino)cyclopent-1-ene (936-52-7) + phosphorous acid (10294-56-1) → N-cyclopentylmorpholine (39198-78-2)

Guidance literature:

upstream raw materials:

C₂₄H₃₈N₂OS₂

1-(N-morpholino)cyclopent-1-ene

morpholine

phosphorous acid

Refernces

• 1、 Firouzabadi, Habib,Iranpoor, Nasser,Alinezhad, Heshmatollah. "Dichlorobis(1,4-diazabicyclo[2.2.2]octane)(tetrahydroborato)zirco- nium(IV), [Zr(BH4)2Cl2(dabco)2](ZrBDC), as a new, stable, and versatile bench top reducing agent: Reduction of imines and enamines, reductive amination of aldehydes and ketones and reductive methylation of amines". . p. 143 - 151. Retrieved 2007/10/03.
• 2、 Abdel-Magid, Ahmed F.,Carson, Kenneth G.,Harris, Bruce D.,Maryanoff, Cynthia A.,Shah, Rekha D.. "Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures". . p. 3849 - 3862. Retrieved 2007/10/03.