13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline

Base Information

• Chemical Name: 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline
• CAS No.: 862306-94-3
• Molecular Formula: C₂₆H₂₃N
• Molecular Weight: 349.475
• Mol file: 862306-94-3.mol

Synonyms:13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline

Chemical Property of 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline

There total 3 articles about 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-iodo-benzyl)-4-p-tolyl-isoquinolinium; bromide + 1,2-propanediene (463-49-0) → 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline (862306-94-3)

Guidance literature:

With indium; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide; at 40 ℃; for 20h; under 750.06 Torr;

DOI:10.1039/b503213j

Reference yield:

4-(4-methylphenyl)isoquinoline → 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline (862306-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 2 h / 80 °C

2: trifuryl phosphine; In; CuI / Pd(OAc)2 / dimethylformamide / 20 h / 40 °C / 750.06 Torr

With indium; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide;

DOI:10.1039/b503213j

Reference yield:

2-Iodobenzyl bromide (40400-13-3) → 13-methylene-5-p-tolyl-8,13,14,14a-tetrahydro-benzo[5,6]azepino[2,1-a]isoquinoline (862306-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 2 h / 80 °C

2: trifuryl phosphine; In; CuI / Pd(OAc)2 / dimethylformamide / 20 h / 40 °C / 750.06 Torr

With indium; copper(l) iodide; trifuran-2-yl-phosphane; palladium diacetate; In N,N-dimethyl-formamide;

DOI:10.1039/b503213j

upstream raw materials:

1,2-propanediene

2-Iodobenzyl bromide