ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate
• CAS No.: 1310453-76-9
• Molecular Formula: C₁₇H₁₉N₃O₂
• Molecular Weight: 297.357
• Mol file: 1310453-76-9.mol

Synonyms:ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate

Chemical Property of ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate

There total 3 articles about ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + m-tolyl aldehyde (620-23-5) + malononitrile (109-77-3) → ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate (1310453-76-9)

Guidance literature:

With ammonium acetate; In ethanol; water; for 0.583333h; Reflux; Green chemistry;

DOI:10.1007/s13738-019-01788-y

Reference yield:

2-(3-methylbenzylidene)malononitrile (15728-26-4) + ethyl acetoacetate (141-97-9) → ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate (1310453-76-9)

Guidance literature:

With ammonium acetate; at 20 ℃; for 0.25h; Neat (no solvent);

DOI:10.1080/00397911.2010.499488

Reference yield:

m-tolyl aldehyde (620-23-5) → ethyl 6-amino-5-cyano-2-methyl-4-(3-methylphenyl)-1,4-dihydropyridine-3-carboxylate (1310453-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / 0.25 h / 20 °C / Neat (no solvent)

2: ammonium acetate / 0.25 h / 20 °C / Neat (no solvent)

With ammonium acetate; 1: Knoevenagel condensation / 2: Michael condensation;

DOI:10.1080/00397911.2010.499488

upstream raw materials:

2-(3-methylbenzylidene)malononitrile

ethyl acetoacetate

m-tolyl aldehyde

malononitrile