C₂₇H₂₉N₅O₄

Base Information

• Chemical Name: C₂₇H₂₉N₅O₄
• CAS No.: 1207359-85-0
• Molecular Formula: C₂₇H₂₉N₅O₄
• Molecular Weight: 487.558
• Mol file: 1207359-85-0.mol

Synonyms:C₂₇H₂₉N₅O₄

Chemical Property of C₂₇H₂₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₉N₅O₄

There total 5 articles about C₂₇H₂₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H25N5O3 + benzoyl chloride (98-88-4) → C27H29N5O4 (1207359-85-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

tert-butyl 2-chloro-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (1207370-38-4) → C27H29N5O4 (1207359-85-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 120 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: tetraalkylammonium carbonate polymer-bound resin / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;

DOI:10.1021/jm301389h

Reference yield:

C25H33N5O5 (1207368-86-2) → C27H29N5O4 (1207359-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

1.2: tetraalkylammonium carbonate polymer-bound resin / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm301389h

upstream raw materials:

benzoyl chloride

tert-butyl 2-chloro-4-morpholino-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid tert-butyl ester

C₂₅H₃₃N₅O₅