Technology Process of (24R)-3β-acetoxy-24-benzoyloxycholest-5-en-7-one
There total 6 articles about (24R)-3β-acetoxy-24-benzoyloxycholest-5-en-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(24R)-3β-acetoxy-24-benzoyloxycholest-5-ene;
With
air; N-hydroxyphthalamide; dibenzoyl peroxide;
In
ethyl acetate; acetone;
at 50 - 60 ℃;
for 48h;
With
pyridine; acetic anhydride;
at 20 ℃;
for 12h;
DOI:10.1248/cpb.51.1177
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine
2.1: aq. AD-mix-β / 2-methyl-propan-2-ol
3.1: 93 percent / pyridine / 20 °C
4.1: 86 percent / pyridine; POCl3 / 12 h / 20 °C
5.1: 63 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
6.1: N-hydroxyphthalamide; benzoyl peroxide; air / ethyl acetate; acetone / 48 h / 50 - 60 °C
6.2: 64 percent / pyridine; Ac2O / 12 h / 20 °C
With
pyridine; air; N-hydroxyphthalamide; AD-mix-β; hydrogen; trichlorophosphate; dibenzoyl peroxide;
palladium on activated charcoal;
In
ethyl acetate; acetone; tert-butyl alcohol;
2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1248/cpb.51.1177
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aq. AD-mix-β / 2-methyl-propan-2-ol
2.1: 93 percent / pyridine / 20 °C
3.1: 86 percent / pyridine; POCl3 / 12 h / 20 °C
4.1: 63 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
5.1: N-hydroxyphthalamide; benzoyl peroxide; air / ethyl acetate; acetone / 48 h / 50 - 60 °C
5.2: 64 percent / pyridine; Ac2O / 12 h / 20 °C
With
pyridine; air; N-hydroxyphthalamide; AD-mix-β; hydrogen; trichlorophosphate; dibenzoyl peroxide;
palladium on activated charcoal;
In
ethyl acetate; acetone; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1248/cpb.51.1177
