(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

Base Information

Chemical Name:(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol
CAS No.:79069-69-5
Molecular Formula:C₁₇H₂₁BrO₄
Molecular Weight:369.255
Hs Code.:

(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiro<bicyclo<2.2.1>heptane-2,2'-<1,3>dioxolane>-7-methanol

Synonyms:(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

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Chemical Property of (1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

Chemical Property:

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Technology Process of (1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

There total 3 articles about (1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79069-64-0
Methyl (-)-(1α,4α,5α,7R*)-5-bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-carboxylate

: 79069-69-5
(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 25 ℃; for 6h;
DOI:10.1021/jo00337a039

Reference yield:

: 100-39-0
benzyl bromide

: 79069-69-5
(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) benzene, DMSO, 1.5 h, 65 deg C, 2) 18 h, 65 deg C

2: 1.06 g / LiAlH₄ / diethyl ether / 6 h / 25 °C

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether;
DOI:10.1021/jo00337a039

Reference yield:

: 79120-26-6
Methyl (+)-(1α,4α,5α,7R*)-5-bromo-7-hydroxyspiroheptane-2,2'-<1,3>dioxolane>-7-carboxylate

: 79069-69-5
(1α,4α,5α,7R*)-5-Bromo-7-(benzyloxy)spiroheptane-2,2'-<1,3>dioxolane>-7-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) benzene, DMSO, 1.5 h, 65 deg C, 2) 18 h, 65 deg C

2: 1.06 g / LiAlH₄ / diethyl ether / 6 h / 25 °C

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether;
DOI:10.1021/jo00337a039