1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

Base Information

Chemical Name:1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester
CAS No.:160517-47-5
Molecular Formula:C₂₃H₃₁N₃O₇S₂
Molecular Weight:525.647
Hs Code.:

Synonyms:1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

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Chemical Property of 1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

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Technology Process of 1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

There total 3 articles about 1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 145709-20-2
6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-3-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

: 160517-47-5
1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 55 ℃; for 2h;
DOI:10.1021/jm00001a017

Reference yield:

: 145457-73-4
2-<<3-nitro-2-<<5-<(tert-butyldimethylsilyl)oxy>pentyl>thio>phenyl>methylene>-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

: 160517-47-5
1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium acetate / dimethylformamide / 4 h / 75 °C

2: 67 percent / 4-(N,N-dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature

3: 76 percent / tetra-n-butylammonium fluoride / tetrahydrofuran; acetonitrile / 2 h / 55 °C

With dmap; tetrabutyl ammonium fluoride; sodium acetate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00001a017

Reference yield:

: 160517-46-4
1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<<5-<(tert-butyldimethylsilyl)oxy>pentyl>thio>-3-nitrophenyl>-5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

: 160517-47-5
1,4-dihydro-6-methyl-2-(methylthio)-4-<2-<(5-hydroxypentyl)thio>-3-nitrophenyl>-5-pyrimidinedicarboxylic acid, 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / 4-(N,N-dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature

2: 76 percent / tetra-n-butylammonium fluoride / tetrahydrofuran; acetonitrile / 2 h / 55 °C

With dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00001a017