(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

Base Information

Chemical Name:(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile
CAS No.:1574531-99-9
Molecular Formula:C₁₄H₁₃FN₄
Molecular Weight:256.282
Hs Code.:

Synonyms:(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

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Chemical Property of (Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

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Technology Process of (Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

There total 3 articles about (Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 153391-41-4
<5-(4-fluorophenyl)-1H-pyrazol-3-yl>acetonitrile

: 1574531-99-9
(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

Guidance literature:: In tetrahydrofuran; at 80 - 90 ℃;
DOI:10.1016/j.tetlet.2014.01.095

Reference yield:

: 153391-26-5
6-(4-fluorophenyl)-4-(methylthio)-2-oxo-2H-pyran-3-carbonitrile

: 1574531-99-9
(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / methanol / Reflux

2: tetrahydrofuran / 80 - 90 °C

With hydrazine; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2014.01.095

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1574531-99-9
(Z)-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)-3-(dimethylamino)acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: hydrazine / methanol / Reflux

3: tetrahydrofuran / 80 - 90 °C

With potassium hydroxide; hydrazine; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2014.01.095