1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

Base Information

Chemical Name:1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline
CAS No.:798565-54-5
Molecular Formula:C₂₃H₂₆ClNO₃
Molecular Weight:399.917
Hs Code.:

Synonyms:1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

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Chemical Property of 1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

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Technology Process of 1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

There total 14 articles about 1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 798565-53-4
[1-(3-sec-butoxy-benzyl)-6,7-dimethoxy-isoquinoline-4-yl]-methanol

: 798565-54-5
1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

Guidance literature:: [1-(3-sec-butoxy-benzyl)-6,7-dimethoxy-isoquinoline-4-yl]-methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

With lithium chloride; at 20 ℃; for 15h;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 798565-54-5
1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 48 h / 65 °C

2.1: sodium hydroxide / methanol; water / 4 h / 60 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 15 h / 20 °C

4.1: phosphorus pentachloride / dichloromethane / 15 h / 20 °C

5.1: sulfur / dichloromethane / 1 h / 155 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

6.2: 0 °C

7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.25 h / 0 °C

7.2: 15 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; water; acetone;

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 798565-54-5
1-(3-sec-butoxy-benzyl)-4-chloromethyl-6,7-dimethoxy-isoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C

1.2: 2 h / 80 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

4.1: phosphorus pentachloride / dichloromethane / 20 °C

5.1: sulfur / 0.25 h / 165 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 2844.39 Torr

7.1: ethanol; sodium / 0.17 h / 20 °C

8.1: DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

9.2: 0 °C

10.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.25 h / 0 °C

10.2: 15 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ethanol; phosphorus pentachloride; hydrogen; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; methanesulfonyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; toluene;