N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Base Information

Chemical Name:N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine
CAS No.:956139-24-5
Molecular Formula:C₃₃H₃₄N₆O₄
Molecular Weight:578.671
Hs Code.:

Synonyms:N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Suppliers and Price of N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

There total 5 articles about N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1415645-70-3
N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

: 956139-24-5
N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 1415645-58-7
7-O-(tert-butyldiphenylsilyl)-N-trityl orpholinoguanosine

: 956139-24-5
N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Molecular sieve; Inert atmosphere

1.2: 2 h / Molecular sieve; Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 75054-94-3
5'-O-(tert-butyldiphenylsilyl)guanosine

: 956139-24-5
N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; ammonium biborate tetrahydrate / methanol / 1.5 h / 10 °C / Molecular sieve; Inert atmosphere

1.2: 2 h / Molecular sieve; Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Molecular sieve; Inert atmosphere

3.2: 2 h / Molecular sieve; Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

With sodium periodate; ammonium biborate tetrahydrate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491