N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

Base Information

Chemical Name:N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine
CAS No.:1415645-70-3
Molecular Formula:C₄₉H₅₂N₆O₄Si
Molecular Weight:817.075
Hs Code.:

Synonyms:N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

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Chemical Property of N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

Chemical Property:

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Technology Process of N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

There total 3 articles about N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1415645-58-7
7-O-(tert-butyldiphenylsilyl)-N-trityl orpholinoguanosine

: 97-72-3
2-Methylpropionic anhydride

: 1415645-70-3
N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

Guidance literature:: 7-O-(tert-butyldiphenylsilyl)-N-trityl orpholinoguanosine; 2-Methylpropionic anhydride; With triethylamine; In N,N-dimethyl-formamide; at 140 ℃; for 3h; Molecular sieve; Inert atmosphere;

With triethylamine; In tetrahydrofuran; for 2h; Molecular sieve; Inert atmosphere;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 75054-94-3
5'-O-(tert-butyldiphenylsilyl)guanosine

: 1415645-70-3
N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate; ammonium biborate tetrahydrate / methanol / 1.5 h / 10 °C / Molecular sieve; Inert atmosphere

1.2: 2 h / Molecular sieve; Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Molecular sieve; Inert atmosphere

3.2: 2 h / Molecular sieve; Inert atmosphere

With sodium periodate; ammonium biborate tetrahydrate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 1415645-52-1
7-O-(tert-butyldiphenylsilyl)morpholinoguanosine

: 1415645-70-3
N-isobutyryl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinoguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 140 °C / Molecular sieve; Inert atmosphere

2.2: 2 h / Molecular sieve; Inert atmosphere

With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491