Technology Process of (S)-N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide
There total 11 articles about (S)-N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: N-chloro-succinimide; aluminum oxide / 40 °C / Microwave irradiation
2: triethylamine / tetrahydrofuran / 1 h / 70 °C / Microwave irradiation
3: water; sodium hydroxide / methanol / 4 h / 60 °C
4: borane-THF / tetrahydrofuran / 0 - 20 °C
5: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
6: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C
7: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
8: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
9: Resolution of racemate
With
1H-imidazole; aluminum oxide; N-chloro-succinimide; borane-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iodine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
5: Appel reaction;
DOI:10.1002/cmdc.201100522
- Guidance literature:
-
Multi-step reaction with 2 steps
1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
2: Resolution of racemate
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1002/cmdc.201100522
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C
2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
4: Resolution of racemate
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100522
