N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Base Information

Chemical Name:N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide
CAS No.:1368806-88-5
Molecular Formula:C₃₈H₄₀N₂O₃S
Molecular Weight:604.813
Hs Code.:

Synonyms:N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Suppliers and Price of N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Chemical Property:

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Technology Process of N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

There total 9 articles about N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1368806-88-5
N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-chloro-succinimide; aluminum oxide / 40 °C / Microwave irradiation

2: triethylamine / tetrahydrofuran / 1 h / 70 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 4 h / 60 °C

4: borane-THF / tetrahydrofuran / 0 - 20 °C

5: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C

7: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

8: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With 1H-imidazole; aluminum oxide; N-chloro-succinimide; borane-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iodine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Appel reaction;
DOI:10.1002/cmdc.201100522

Reference yield:

: C₁₆H₂₂N₂O₂

: 75286-49-6,75368-95-5
S-trityl-2-mercaptopropionic acid

: 1368806-88-5
N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/cmdc.201100522

Reference yield:

: 1136-45-4
5-methyl-3-phenylisoxazol-4-carboxylic acid

: 1368806-88-5
N-{5-[(5-methyl-3-phenylisoxazol-4-yl)methoxy]pentyl}-2-(tritylthio)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With 1H-imidazole; borane-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Appel reaction;
DOI:10.1002/cmdc.201100522