3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Base Information

• Chemical Name: 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine
• CAS No.: 321907-00-0
• Molecular Formula: C₂₃H₄₁N₅O₃Si
• Molecular Weight: 463.696
• Mol file: 321907-00-0.mol

Synonyms:3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Chemical Property of 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

There total 5 articles about 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

8-cyclohexyl-3-(3-phthalimidopropyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321906-99-4) → 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321907-00-0)

Guidance literature:

With methylamine; In methanol; at 50 ℃; for 14h;

DOI:10.1021/jm000181f

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321907-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 97 percent / dimethylformamide

2.1: 89 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h

3.1: K₂CO₃ / dimethylformamide / 1 h

3.2: 100 percent / dimethylformamide

4.1: 56 percent / CH₃NH₂ / methanol / 14 h / 50 °C

With ammonium formate; potassium carbonate; methylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm000181f

Reference yield:

3-benzyl-8-cyclohexyl-1-propyl-3,7-dihydro-purine-2,6-dione → 3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321907-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 97 percent / dimethylformamide

2.1: 89 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h

3.1: K₂CO₃ / dimethylformamide / 1 h

3.2: 100 percent / dimethylformamide

4.1: 56 percent / CH₃NH₂ / methanol / 14 h / 50 °C

With ammonium formate; potassium carbonate; methylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm000181f

upstream raw materials:

8-cyclohexyl-3-(3-phthalimidopropyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

(2-trimethylethylsilylethoxy)methyl chloride

8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

3-benzyl-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Downstream raw materials:

8-cyclohexyl-3-(3-(4-fluorosulfonylbenzamido)propyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine