8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Base Information

• Chemical Name: 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine
• CAS No.: 321906-97-2
• Molecular Formula: C₂₀H₃₄N₄O₃Si
• Molecular Weight: 406.6
• Mol file: 321906-97-2.mol

Synonyms:8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Chemical Property of 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

There total 4 articles about 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-benzyl-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321906-87-0) → 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321906-97-2)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1021/jm000181f

Reference yield:

3-benzyl-8-cyclohexyl-1-propyl-3,7-dihydro-purine-2,6-dione → 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321906-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: ammonium formate; 10 percent Pd/C / methanol / Heating

With palladium on activated charcoal; ammonium formate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00639-X

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine (321906-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 97 percent / dimethylformamide

2.1: 89 percent / ammonium formate / 10 percent Pd/C / methanol / 2 h

With ammonium formate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm000181f

upstream raw materials:

3-benzyl-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

8-cyclohexyl-3-(4-fluorosulfonylbenzyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

8-cyclohexyl-3-(3-(4-fluorosulfonylphenyl)propyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

8-cyclohexyl-3-(3-(4-fluorosulfonylbenzamido)propyl)-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine

3-(3-aminopropyl)-8-cyclohexyl-1-propyl-7-(2-(trimethylsilyl)ethoxymethyl)xanthine