2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Base Information

• Chemical Name: 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• CAS No.: 862080-84-0
• Molecular Formula: C₂₉H₄₈O₈SSi₂
• Molecular Weight: 612.932

Synonyms:2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Chemical Property of 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

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Technology Process of 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

There total 4 articles about 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-81-7) → 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ4-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-84-0) + 2,4-Dimethoxy-benzoic acid (1R,2S,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ4-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester

Guidance literature:

With Davis oxaziridine reagent; In chloroform; at 0 ℃; for 4h;

DOI:10.1021/jo0506985

Reference yield:

C11H18O3S (849112-79-4) → 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ4-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-84-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 91 percent / aq. HCl / tetrahydrofuran / 8 h / 20 °C

2.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

3.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

3.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

4.1: 75 percent / Davis oxaziridine reagent / CHCl₃ / 4 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; Davis oxaziridine reagent; silver nitrate; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jo0506985

Reference yield:

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol (862080-75-9) → 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ4-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

2.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

2.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

3.1: 75 percent / Davis oxaziridine reagent / CHCl₃ / 4 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; Davis oxaziridine reagent; silver nitrate; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jo0506985

upstream raw materials:

2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

C₁₁H₁₈O₃S

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol

2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

Downstream raw materials:

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2-amino-6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-7,7,9,9-tetraisopropyl-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

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